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| Holoprosencephaly Articles

Evaluation and management of children with holoprosencephaly.
A report by CARTER CENTERS doctors.


Brains and faces in holoprosencephaly: pre- and postnatal description of 30 cases
Describes the sonographic appearance and the pre- and postnatal clinical data of HPE in a study group of 30 fetuses. We compare our findings with results from prenatal and postnatal studies and reviews, and discuss epidemiological aspects and etiological alternatives responsible for the HPE spectrum.
A syndrome of holoprosencephaly, recurrent infections, and monocytosis.
Deswcribes three siblings with holoprosencephaly, microcephaly, severe developmental delay, failure to thrive, and brachydactyly. Laboratory studies showed a peripheral blood monocytosis with markedly abnormal morphology. This is the first report demonstrating an association between abnormal mononuclear phagocytes and holoprosencephaly.
Hypernatremia After Cleft Lip Repair in a Patient with Holoprosencephaly

RISK FACTORS FOR THE DEVELOPMENT OF HOLOPROSENCEPHALY: A MANITOBA-BASED CASE-CONTROL STUDY
Examines potential risk factors contributing to the occurrence of holoprosencephaly (HPE) in Manitoba.
A retrospective survey of perinatal risk factors of 104 living children with holoprosencephaly
A CARTER CENTERS study: Describes prenatal genetic and environmental factors and birth outcomes in a population of 104 children with holoprosencephaly.
Genetics and HPE
Discusses the clinical presentations and pathogenesis of HPE.

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